PERIPrem (Perinatal Excellence in Reducing Injury in Premature birth) is a bundle of perinatal care interventions designed to reduce the risk of injury and death in pre-term babies.

Babies born prematurely are at risk of lifelong brain damage or death. In the South West of England, rates of brain damage among pre-term babies is higher than in other regions of the UK. Perinatal clinical care interventions can reduce mortality in pre-term newborns and increase the chances of very pre-term babies enjoying bright futures free from brain injury.

Developed by the West of England AHSN with obstetric and neonatal teams at University Hospitals Bristol NHS Foundation Trust and Great Western Hospitals NHS Foundation Trust, the bundle comprises 11 evidence-based care interventions designed to improve rates of survival free from brain injury in premature newborns.


Throughout 2020 the South West AHSN worked in collaboration with the West of England AHSN to roll out the PERIPrem bundle across NHS trusts in the West and South West of England. The latest data for the South West (September 2020-May 2021) can be viewed here.

As of April 2021, PERIPrem merged into the NHSE-commissioned Maternal and Neonatal Safety Improvement Programme (known as MatNeoSIP).

In June 2021, PERIPrem was shortlisted for a 2021 HSJ Patient Safety Award.

Please visit the West of England AHSN website to learn more about each of the PERIPrem bundle elements.

The PERIPrem programme supported the aim of the NHS Long Term Plan (LTP), which has made reducing neonatal mortality and serious brain injury a priority for the next decade. PERIPrem also aligns with the strategic aims of the South West Neonatal Operational Delivery Network (ODN) and builds on the work the network has done in supporting the South West’s 12 regional units to improve outcomes for pre-term babies.

In addition to improving clinical outcomes for neonates, PERIPrem is expected to develop perinatal team culture at unit level and increase quality improvement (QI) capability within the South West region.

The PERIPrem project team committed to identifying the top 8 languages spoken across our geography to help ensure equity of access within the project. This resulted in the translation of our parent facing co designed resources (Maternal Early Breast Milk leaflet and Parent Passport) targeted towards the volume of parents who would receive most benefit across the South West. These resources have been shared with the perinatal system and they remain a free resource for all to access on the PERIPrem website.